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KMID : 1134820070360050534
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 5 p.534 ~ p.539
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Acute Toxicity of Leuconostoc citreum GJ7 Isolated from Kimchi in Mice
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Lee Jae-Joon
Chang Hae-Choon
Lee Myong-Ryeol
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Abstract
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The present study was carried out to investigate the potential acute toxicity of Leuconostoc citreum GJ7 (Leu. citreum GJ7), a lactic acid bacterium isolated from Kimchi, in ICR male and female mice. The test article was administered to the mice orally or intraperitoneally. Mortality rates, clinical findings, and body weight changes were monitored for the 2 weeks following administration. The results showed that in 50% of the cases, lethal doses (LD??) of Leu. citreum GJ7 were determined as ＞5,000 ㎎/㎏ (p.o.) and >2,500 ㎎/㎏ (i.p.) in both sexes. There were no significant changes in general conditions, body weights, clinical signs and any gross lesions between vehicle control and Leu. citreum GJ7-treated groups. Hence, it is suggested that Leu. citreum GJ7 does not induce any significant acute toxicity in ICR mice.
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KEYWORD
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Leuconostoc citreum GJ7, acute toxicity, mice
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